| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1053 | |
| Phytochemical name or plant extracts | Ginnalin A | |
| PMID | 23122108 | |
| Literature evidence | Ginnalin A did not induce apoptosis of the cancer cells but arrested cell cycle (in the S- and G(2)/M-phases) and decreased cyclins A and D1 protein levels. | |
| IUPAC name | [(2R,3S,4S,5S)-3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxyoxan-2-yl]methyl 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Acer rubrum | |
| Geographical availability | Alabama, Arkansas, Delaware, Florida, Georgia, Illinois, Indiana, Kentucky, Maryland, Minnesota, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Dakota, Ohio, Ontario, Pennsylvania, Québec, South Carolina, South Dakota, Tennessee, Texas, Vermont, Virginia, Wisconsin | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | Cyclin A, Cyclin D1 | |
| Gene or Protein evidence | Ginnalin A did not induce apoptosis of the cancer cells but arrested cell cycle (in the S- and G(2)/M-phases) and decreased cyclins A and D1 protein levels. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results suggest that maple polyphenols may have potential cancer chemopreventive effects mediated through cell cycle arrest. | |
| Cell line/ mice model | MCF-7, HCT-116 | |
| Additional information | Recently, ginnalin A has also been reported to prevent TRAIL-induced apoptosis in human keratinocytes | |
| PubChem ID | 5318457 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1867-2 | |
| Safety | NA |