| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1115 | |
| Phytochemical name or plant extracts | Ginkgolic acid C13:0 | |
| PMID | 28402272 | |
| Literature evidence | Ginkgolic acids (GA), a group of alkyl phenols found in crude extracts of Ginkgo biloba leaves, are known to have anticancer activity, but their mode of action is not well understood. | |
| IUPAC name | 2-hydroxy-6-tridecylbenzoic acid | |
| Phytochemicals’ class or type of plant extracts | Ginkgolic acid | |
| Source of phytochemicals or plant Extracts | Ginkgo biloba | |
| Geographical availability | China Southeast | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | uPA, PAI-1, CXCR4, MMP9 | |
| Gene or Protein evidence | Ginkgolic acids downregulate the expression of the uPA, PAI-1, CXCR4 and MMP-9 genes | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 and MDA-MB 231 | |
| Additional information | NA | |
| PubChem ID | 161306 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:262125-1 | |
| Safety | We conclude that GA revealed considerable anti-migratory activity at non-cytotoxic concentrations, indicating anti-metastatic activity with low toxicity. |