| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1882 | |
| Phytochemical name or plant extracts | Germacrone | |
| PMID | 27573551 | |
| Literature evidence | Clinically, the inhibition of ERα-mediated gene expression in breast cancer cells has long been considered an effective way to prevent the development and progression of cancer. | |
| IUPAC name | (3E,7E)-3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Curcuma wenyujin | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Myanmar, Nepal, Sri Lanka, Thailand, Tibet, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | TFF1, GREB1, CCND1, ERG3, PKIB, CTSD, CXCL12, PGR, MYC | |
| Gene or Protein evidence | Germacrone treatment significantly reduced the mRNA level of TFF1, GREB1, and PGR, which are well-known ERα target genes. The expression of CCND1 and MYC, which are other ERα target genes involved in cell cycle, was also significantly inhibited by germacrone. Compared with the gene expression of cells treated with DMSO (vehicle), the E2-induced expression of TFF1, GREB1, CCND1, ERG3, PKIB, CTSD, CXCL12, PGR, and MYC was significantly reduced following treatment of MCF-7 cells with germacrone | |
| Target pathways | ERα signaling pathway. | |
| IC50 | NA | |
| Potency | Germacrone inhibits the recruitment of ERα to the estrogen response element on chromatin and consequently compromises the binding of switch/sucrose non-fermentable chromatin remodeling complex and RNA polymerase II to target gene promoter, thereby inhibiting the estrogen-induced chromatin accessibility. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In addition, germacrone efficiently potentiates the antitumor activity of methotrexate and 5-fluorouracil. | |
| PubChem ID | 6436348 | |
| Additional PMIDs | 27573551 29655913 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1009084-1 | |
| Safety | NA |