| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1768 |
| Phytochemical name or plant extracts | Geranyl (3-GAP) |
| PMID | 22223344 |
| Literature evidence | In 3-GAP-treated MCF-7 cells, nuclear accumulation and transcriptional activity of p53 were increased. |
| IUPAC name | 3-Geranyl-2,4,6-trihydroxyacetophenone |
| Phytochemicals’ class or type of plant extracts | Phloroacetophenone |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer, Sarcoma |
| Target gene or protein | p53, cyt-c, Bax, Caspase 3, Caspase 7, Caspase 9 |
| Gene or Protein evidence | In 3-GAP-treated MCF-7 cells, nuclear accumulation and transcriptional activity of p53 were increased. In accordance with the Bax increase, 3-GAP induced mitochondrial cytochrome c release and activated caspase-9, an initiator of the caspase cascade. In the MCF-7 cell line which does not express caspase-3, activation of caspase-7, a member of the caspase-3 subfamily, was increased by 3-GAP. The present results indicate that synthetic 3-GAP is a safe and effective anti-cancer agent, and the Bax-mediated mitochondrial pathway is the main apoptosis signaling pathway of 3-GAP in MCF-7 cells. |
| Target pathways | The present results indicate that synthetic 3-GAP is a safe and effective anti-cancer agent, and the Bax-mediated mitochondrial pathway is the main apoptosis signaling pathway of 3-GAP in MCF-7 cells. |
| IC50 | 5.3 μM against MCF-7 |
| Potency | NA |
| Cell line/ mice model | MCF-7, HT1080 |
| Additional information | NA |
| PubChem ID | NA |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |