| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1873 | |
| Phytochemical name or plant extracts | Geraniin | |
| PMID | 27097871 | |
| Literature evidence | Geraniin could generate intracellular reactive oxygen species (ROS), activate p38 MAPK then induce the apoptosis in MCF-7 cells, such phenomena was abrogated by pretreatment with N-acetyl-l-cysteine. | |
| IUPAC name | [(1R,7R,8S,26R,28S,29R,38R)-1,13,14,15,18,19,20,34,35,39,39-undecahydroxy-2,5,10,23,31-pentaoxo-6,9,24,27,30,40-hexaoxaoctacyclo[34.3.1.04,38.07,26.08,29.011,16.017,22.032,37]tetraconta-3,11,13,15,17,19,21,32,34,36-decaen-28-yl] 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Ellagitannin | |
| Source of phytochemicals or plant Extracts | Phyllanthus urinariainn Nephelium lappaceum | |
| Geographical availability | Phyllanthus urinaria - Andaman Is., Assam, Bangladesh, Borneo, Cambodia, Caroline Is., China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Japan, Jawa, Korea, Laccadive Is., Laos, Lesser Sunda Is., Malaya, Maldives, Marianas, Myanmar, Nansei-shoto, New Guinea, Nicobar Is., Northern Territory, Ogasawara-shoto, Pakistan, Philippines, Queensland, South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya, Western Australia Nephelium lappaceum L. - Borneo, China South-Central, China Southeast, Hainan, Malaya, Maluku, Myanmar, Philippines, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Nephelium lappaceum L. rind | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, PARP, Caspase 3 | |
| Gene or Protein evidence | Geraniin induced phosphorylation of the anti-apoptotic Bcl-2, and the cleavage of poly (ADP-ribose) polymerase (PARP) and caspase-3 in MCF-7 cells. | |
| Target pathways | In general, these results support the conclusion that Geraniin-induced apoptosis is mediated via ROS-mediated stimulation of p38 MAPK signaling. | |
| IC50 | 9.94 µM against MCF-7 | |
| Potency | In the present study, we found that Geraniin showed potent anti-proliferative effects on human breast cancer MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Geraniin could generate intracellular reactive oxygen species (ROS), activate p38 MAPK then induce the apoptosis in MCF-7 cells, such phenomena was abrogated by pretreatment with N-acetyl-l-cysteine. | |
| PubChem ID | 3001497 | |
| Additional PMIDs | 30327602 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:354815-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:783833-1 | |
| Safety | NA |