| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1806 | |
| Phytochemical name or plant extracts | Genkwanin VIII | |
| PMID | 24059652 | |
| Literature evidence | RESULTS: After confirmation of the anti-tumor activity, the 95% ethanolic extract was subjected to successive solvent partitioning to petroleum ether, dichloromethane, n-butanol, and water soluble fractions. | |
| IUPAC name | (1R,2R,6S,7S,8R,10S,11S,12R,16R,18R)-6,7-dihydroxy-8-(hydroxymethyl)-4,18-dimethyl-14-phenyl-16-prop-1-en-2-yl-9,13,15,19-tetraoxahexacyclo[12.4.1.01,11.02,6.08,10.012,16]nonadec-3-en-5-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Daphne genkwa, Daphne mezereum | |
| Geographical availability | Daphne genkwa - China North-Central, China South-Central, China Southeast, Japan, Korea, Taiwan Daphne mezereum - Albania, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, Czechoslovakia, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Italy, Kazakhstan, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Romania, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Ukraine, West Siberia, Yugoslavia | |
| Plant parts | Dried flowers buds | |
| Other cancers | Breast cancer, Stomach cancer, Colorectal cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 48 μg/mL against MCF-7 >60 μg/mL against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, Huh7, AGS, HT-29, B 16, Colo 205, A549, A2058 | |
| Additional information | NA | |
| PubChem ID | 442018 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:831227-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:831294-1 | |
| Safety | NA |