| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1226 | |
| Phytochemical name or plant extracts | Genipin | |
| PMID | 21935467 | |
| Literature evidence | In summary, our studies demonstrate that i) the Warburg Effect is mediated by UCP2, ii) UCP2 is over-expressed in breast and many other cancers, iii) UCP2 promotes tumorigenic properties in vitro and in vivo and iv) genipin suppresses the tumor promoting function of UCP2. | |
| IUPAC name | methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Iridoid monoterpenoid | |
| Source of phytochemicals or plant Extracts | Rothmannia wittii | |
| Geographical availability | E. Asia - southern China, Japan, Cambodia, Laos, Vietnam. | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | UCP2 | |
| Gene or Protein evidence | This effect of genipin was in part mediated by a decrease in mitochondrial membrane potential and down-regulation of UCP2 gene expression. | |
| Target pathways | NA | |
| IC50 | 7 uM against MCF-7 | |
| Potency | Genipin was shown to be a chemopreventive agent for preventing metastatic breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, NCI-H187, T47D | |
| Additional information | Genipin inhibits UCP2-mediated proton leak and has been shown to reverse obesity, as well as high glucose-induced beta cell dysfunction in isolated pancreatic islets | |
| PubChem ID | 442424 | |
| Additional PMIDs | 21935467 29634066 26218335 27451963 27431771 22020372 32056374 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:765165-1 | |
| Safety | acute toxic in pubchem database |