| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2191 | |
| Phytochemical name or plant extracts | Gelomulide K | |
| PMID | 21641992 | |
| Literature evidence | In terms of structure-activity relationships, analysis not only showed a correlation between ROS levels and drug activity but also highlighted the importance of the 8,14-epoxy group. | |
| IUPAC name | [(1S,3R,8R,10S,11R,12R,16R)-5,11,15,15-tetramethyl-6-oxo-2,7-dioxapentacyclo[8.8.0.01,3.04,8.011,16]octadeca-4,13-dien-12-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Abietane diterpenoid | |
| Source of phytochemicals or plant Extracts | Suregada aequorea | |
| Geographical availability | Philippines, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP-1 | |
| Gene or Protein evidence | Additionally, in a xenograft model, gelomulide K induced PARP-1 activation and reduced tumor growth. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, our results show that enhancement of paclitaxel activity can be achieved with gelomulide K and that the structurally relevant pharmacophore provides important insight into the development of new caspase-independent cell death-inducing agents. | |
| Cell line/ mice model | Xenograft model | |
| Additional information | NA | |
| PubChem ID | 24775057 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:356642-1 | |
| Safety | Here, we report that gelomulide K acts as a caspase-independent cell death-inducing agent that synergizes with paclitaxel in breast cancer cells and has low toxicity in normal cells. |