| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-59 | |
| Phytochemical name or plant extracts | Gedunin | |
| PMID | 18816111 | |
| Literature evidence | Gedunin (1), a tetranortriterpenoid isolated from the Indian neem tree ( Azadirachta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors. | |
| IUPAC name | [(1S,2R,4S,7S,8S,11R,12R,17R,19R)-7-(furan-3-yl)-1,8,12,16,16-pentamethyl-5,15-dioxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-en-19-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Tetranortriterpenoid | |
| Source of phytochemicals or plant Extracts | Azadirachta indica | |
| Geographical availability | Assam, Bangladesh, Cambodia, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Hsp90 | |
| Gene or Protein evidence | Gedunin, a novel hsp90 inhibitor | |
| Target pathways | NA | |
| IC50 | 8.84 ± 0.03 μM against MCF-7 3.22 ± 0.6 μM against SKBR-3 | |
| Potency | Gedunin (1), a tetranortriterpenoid isolated from the Indian neem tree ( Azadirachta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors. | |
| Cell line/ mice model | MCF-7, SKBR-3 | |
| Additional information | NA | |
| PubChem ID | 12004512 | |
| Additional PMIDs | 20798912 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1213180-2 | |
| Safety | NA |