| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1791 | |
| Phytochemical name or plant extracts | Garlic extract | |
| PMID | 23050048 | |
| Literature evidence | These findings provide a better understanding of the cellular responses to dietary supplements and provide potential options to treat breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Allium sativum | |
| Geographical availability | Iran, Kazakhstan, Kirgizstan, Tadzhikistan, Turkmenistan, Uzbekistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | hsp27, sam68 | |
| Gene or Protein evidence | We observed that 4-6 hours of GE treatment down-modulated the levels of sam68 and hsp27, and subsequently their expression levels were completely lost by 16 hours | |
| Target pathways | NA | |
| IC50 | 2.5 mg/mL against MCF-7 | |
| Potency | These findings provide a better understanding of the cellular responses to dietary supplements and provide potential options to treat breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, U937, U-87 | |
| Additional information | Garlic reportedly inhibited the growth of tumors in mice,13 aged garlic extract (AGE) reduced the risk of cancer and prevented the decline of natural killer (NK) cells in patients with advanced cancer. | |
| PubChem ID | 65036 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528796-1 | |
| Safety | NA |