| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1303 | |
| Phytochemical name or plant extracts | Garcinone C | |
| PMID | 24555285 | |
| Literature evidence | Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay. | |
| IUPAC name | 1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Garcinia mangostana | |
| Geographical availability | Borneo, Malaya | |
| Plant parts | Pericarp, Fruits | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Nasopharyngeal cancer | |
| Target gene or protein | CDK2 | |
| Gene or Protein evidence | The results suggest that the position of key functional groups including hydroxyl and isoprenyl groups contribute to the CDK2 inhibitory effect. | |
| Target pathways | NA | |
| IC50 | 7.1 ± 0.5 µM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, A549, Hep-G2, CNE, 22Rν1and MDA-MB-231 | |
| Additional information | Inhibits CDK2/CyclinE1 (22Rν1and MDA-MB-231) | |
| PubChem ID | 44159808 | |
| Additional PMIDs | 32691623 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428073-1 | |
| Safety | NA |