| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1268 | |
| Phytochemical name or plant extracts | Ganoderma lucidum extract | |
| PMID | 30108589 | |
| Literature evidence | Collectively, this study demonstrated that ESG would serve as a natural anticancer adjuvant via a restoration on the exhausted Tc, highlighting important clinical implications for the treatment of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Ganoderma lucidum | |
| Geographical availability | China, Japan, and other Asian countries. | |
| Plant parts | Spores | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | EGFR, Bax, Cyclin D1, p21/Waf1 | |
| Gene or Protein evidence | Therapeutic potential of Ganoderma lucidum extract (GLE) in breast cancer, focusing on the regulation of the EGFR signaling cascade when treated with the EGFR. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose- and time-dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and not by the immune system. | |
| Target pathways | Rac/Lamellipodin pathway, The mechanisms might be mediated through up-regulation of the expression of p21/Waf1-a cell cycle inhibitor, down-regulation cyclin D1, and up-regulation of a pro-apoptotic BAX protein pathway. | |
| IC50 | NA | |
| Potency | The cells were treated with a series of concentrations of alcohol extract of Ganoderma lucidum from 100–500 ?g/ml for 0, 12, 24, 36 and 48 hr, Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines(MDA-MB-231 and Umbilical vein endothelial cells) in a dose-dependent manner from 2 to 40 micro g/ml. | |
| Cell line/ mice model | MCF-7 human breast cancer cell, MDA-MB-231 cells, prostate cancer PC-3 cell, human umbilical vein endothelial cells. | |
| Additional information | Some of the samples of Ganoderma lucidum demonstrated strong inhibition of cancer cell migration comparable to the inhibition of constitutively active NF-kappaB, Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9, the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities. | |
| PubChem ID | NA | |
| Additional PMIDs | 12397644 26958085 30837881 31109134 22745075 | |
| Additional sources of information | https://www.ncbi.nlm.nih.gov/books/NBK92757/ | |
| Safety | NA |