| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1060 | |
| Phytochemical name or plant extracts | Gamma-linolenic acid (GLA) | |
| PMID | 16264182 | |
| Literature evidence | Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. | |
| IUPAC name | (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid | |
| Phytochemicals’ class or type of plant extracts | Polyunsaturated fatty acid | |
| Source of phytochemicals or plant Extracts | Anemone cylindrica | |
| Geographical availability | Alberta, Arizona, British Columbia, Colorado, Connecticut, Idaho, Illinois, Indiana, Iowa, Kansas, Maine, Manitoba, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New Mexico, New York, North Dakota, Ohio, Ontario, Pennsylvania, Québec, Rhode I., Saskatchewan, South Dakota, Vermont, Wisconsin, Wyoming | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Ovarian cancer, Stomach cancer | |
| Target gene or protein | Her-2/neu | |
| Gene or Protein evidence | Flow cytometric and immunoblotting analyses demonstrated that GLA treatment substantially reduced Her-2/neu protein levels | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | GLA-induced transcriptional repression of Her-2/neu oncogene may represent a potential molecular approach to treating Her-2/neu–overexpressing carcinomas | |
| Cell line/ mice model | BT-474, SK-Br3, MDA-MB-453, SK-OV3, NCI-N87 | |
| Additional information | NA | |
| PubChem ID | 5280933 | |
| Additional PMIDs | 16264182 8386494 15138577 7579484 11239764 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:708323-1 | |
| Safety | NA |