| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1111 | |
| Phytochemical name or plant extracts | Gambogenic acid | |
| PMID | 24460340 | |
| Literature evidence | Gambogenic acid anti-cancer activity in vitro has been reported in several studies, including an A549 nude mouse model. | |
| IUPAC name | (Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methylbut-2-enyl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-2-methylbut-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Polyprenylated Xanthone | |
| Source of phytochemicals or plant Extracts | Garcinia hanburyi | |
| Geographical availability | Cambodia, Laos, Thailand, Vietnam | |
| Plant parts | Gamboge | |
| Other cancers | Breast cancer | |
| Target gene or protein | Fas, Caspase 3,-8,-9, Bax, Bcl-2 | |
| Gene or Protein evidence | We found that gambogenic acid suppressed breast tumor growth in vivo, in association with increased expression of Fas and cleaved caspase-3,-8,-9 and bax, as well as decrease in the anti-apoptotic protein bcl-2 | |
| Target pathways | Our results first confirmed that GNA could effectively induce the apoptosis of breast cancer via the death receptor and mitochondrial pathways. | |
| IC50 | 0.78 µg/ml against MDA-MB-231 | |
| Potency | Gambogenic acid inhibited cell proliferation and induced cell apoptosis in a concentration-dependent manner. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Gambogenic acid can inhibite the proliferation and invasion of HeLa cells,and promote the cells apoptosis in a concentration dependent manner. | |
| PubChem ID | 10794070 | |
| Additional PMIDs | 26066793 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:427987-1 | |
| Safety | NA |