| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-883 | |
| Phytochemical name or plant extracts | Gallic acid | |
| PMID | 32996435 | |
| Literature evidence | The anticancer activity of isolated compounds (1) and (2) were evaluated by in vitro assays against two human cancer cell lines namely, HeLa (Cervical) and MDA-MB231 (Breast) cancer cells revealed that IC50 values of gallic acid (HeLa: 4.179197 ± 0.45 µg/ml, MDA-MB231: 80.0427 ± 0.19 µg/ml at 24 h) and quercetin (HeLa: 99.914 ± 0.18 µg/ml, MDA-MB231: 18.288382 ± 0.12 µg/ml at 24 h), respectively. | |
| IUPAC name | 3,4,5-trihydroxybenzoic acid | |
| Phytochemicals’ class or type of plant extracts | Phenolic acid | |
| Source of phytochemicals or plant Extracts | Ceriops tagal | |
| Geographical availability | Ceriops tagal - Aldabra, Andaman Is., Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China Southeast, Comoros, Djibouti, Hainan, India, Jawa, Kenya, KwaZulu-Natal, Laccadive Is., Lesser Sunda Is., Madagascar, Malaya, Maluku, Mozambique, Mozambique Channel I, Myanmar, New Caledonia, New Guinea, New South Wales, Nicobar Is., Northern Territory, Pakistan, Philippines, Queensland, Seychelles, Solomon Is., Somalia, Sri Lanka, Sulawesi, Sumatera, Tanzania, Thailand, Vanuatu, Vietnam, Western Australia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | EGFR, Src, AKT/p65, MMP9 | |
| Gene or Protein evidence | Gallic acid repressed the EGF-induced activation of EGFR and Src, furthermore, inactivation of Akt/p65 and ERK/c-Jun was a result of the inhibitory effect of gallic acid on the EGF-induced MMP-9 up-regulation. | |
| Target pathways | Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells. | |
| IC50 | 80.0427 ± 0.19 µg/ml against MDA-MB-231 36.0± 1.7 µg/ml against MCF-7 | |
| Potency | Gallic acid (GA), a polyhydroxylphenolic compound abundantly distributed in plants, fruits, and foods, has been reported to have various biological activities including an anticancer effect. | |
| Cell line/ mice model | HeLa, MDA-MB23, MCF-7 | |
| Additional information | Moreover, gallic acid could moderate MSU-induced macrophages and neutrophils migration into joint synovitis. In summary, we found that gallic acid suppresses ROS generation, thereby limiting NLRP3 inflammasome activation and pyroptosis dependent on Nrf2 signaling, suggesting that gallic acid possesses therapeutic potential for the treatment of gouty arthritis. | |
| PubChem ID | 370 | |
| Additional PMIDs | 26047480 27087131 24864015 33365024 31956296 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:719711-1 | |
| Safety | NA |