| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-903 | |
| Phytochemical name or plant extracts | Galbanic acid | |
| PMID | 21484672 | |
| Literature evidence | Compared to verapamil, the well-known inhibitor of P-gp, galbanic acid (5, 10, and 25 µg/mL), significantly inhibited the P-gp activity. | |
| IUPAC name | 3-[(1S,2S,3S)-2,3-dimethyl-2-[(2-oxochromen-7-yl)oxymethyl]-6-propan-2-ylidenecyclohexyl]propanoic acid | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Ferula szowitsiana | |
| Geographical availability | Afghanistan, Iran, Transcaucasus, Turkey, Turkmenistan, Uzbekistan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results indicate that the plant derived sesquiterpene coumarins, farnesiferol A and galbanic acid, may be promising candidates to be considered for further studies on the reversal of multidrug resistance phenotype in chemotherapy of cancer patients. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Galbanic acid decreased proliferation, cell cycle progression, and survival of glioblastoma cells through inhibiting the PI3K/Akt/mTOR pathway. | |
| PubChem ID | 7082474 | |
| Additional PMIDs | 32394847 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842521-1 | |
| Safety | NA |