| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-827 | |
| Phytochemical name or plant extracts | Galangin | |
| PMID | 9066718 | |
| Literature evidence | Baicalein, galangin, hesperetin, naringenin and quercetin apparently exert their antiproliferative activity via some other mechanism. | |
| IUPAC name | 3,5,7-trihydroxy-2-phenylchromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Phenol | |
| Source of phytochemicals or plant Extracts | Alpinia officinarum | |
| Geographical availability | Cambodia, China Southeast, Hainan, Myanmar, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Esophageal cancer | |
| Target gene or protein | STAT-3, p-JAK2, Bcl-2, Caspase 3, PARP, Ki67, Nrf2 , NQO-1, HO-1, GSTP1-1 | |
| Gene or Protein evidence | STAT3 overexpression also counteracted excessive ROS accumulation induced by galangin. Consistent with the in vitro experiments, in nude mice exnografted with MGC 803 cells, galangin inhibited tumor growth and reversed the abnormally expressed proteins, such as p-JAK2, p-STAT3, Bcl-2, cleaved caspase-3, cleaved PARP, and Ki67. Meanwhile, galangin increased ROS accumulation, and reduced Nrf2 and NQO-1, but elevated HO-1 in MGC 803 cells. Especially galangin was able to inhibit almost all cellular GSTP1-1 activity upon exposure of the cells to a concentration of 25microM. | |
| Target pathways | JAK2/STAT3 pathway, STAT3/ROS axis | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HCT-116, HeLa, BT-474, MGC 803 | |
| Additional information | Taken together, galangin was suggested to inhibit the growth of MGC 803 cells through inducing apoptosis and decreasing cell proliferation, which might be mediated by modulating STAT3/ROS axis. | |
| PubChem ID | 5281616 | |
| Additional PMIDs | 33981228 32454600 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:795246-1 | |
| Safety | NA |