| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-262 | |
| Phytochemical name or plant extracts | Gaillardin | |
| PMID | 26843455 | |
| Literature evidence | The ability to induce apoptosis is an important property of a candidate anticancer drug, which discriminates between anticancer drugs and toxic compounds. | |
| IUPAC name | Arizona, Colorado, Kansas, Mexico Northeast, Mexico Northwest, Missouri, Nebraska, New Mexico, Oklahoma, South Dakota, Texas | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Gaillardia pulchella | |
| Geographical availability | Arizona, Colorado, Kansas, Mexico Northeast, Mexico Northwest, Missouri, Nebraska, New Mexico, Oklahoma, South Dakota, Texas | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, p53, Bcl-2 | |
| Gene or Protein evidence | Gaillardin upregulated the pro-apoptotic protein Bax and p53 and downregulated the anti-apoptotic protein Bcl-2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Gaillardin can inhibit proliferation of breast cancer cells via inducing mitochondrial apoptotic pathway and therefore, might be a promising molecule in cancer chemoprevention or chemotherapy. | |
| Cell line/ mice model | MCF-7, MDA-MB-468 | |
| Additional information | Taken together, these results demonstrate that Gaillardin can inhibit proliferation of breast cancer cells via inducing mitochondrial apoptotic pathway and therefore, might be a promising molecule in cancer chemoprevention or chemotherapy. | |
| PubChem ID | 267247 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:329185-2 | |
| Safety | NA |