| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1826 | |
| Phytochemical name or plant extracts | Furanodiene | |
| PMID | 24824922 | |
| Literature evidence | In this study, we demonstrated that at low concentrations (5-25μM), furanodiene inhibited adhesion, migration and invasion of breast cancer cells, but it did not induce cytotoxicity, apoptosis and cell cycle arrest. | |
| IUPAC name | (5E,9E)-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Curcuma wenyujin | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Myanmar, Nepal, Sri Lanka, Thailand, Tibet, Vietnam | |
| Plant parts | Major components of volatile oil | |
| Other cancers | Breast cancer | |
| Target gene or protein | integrin αV , β-catenin, FAK, AKT, PI3 kinase p85 | |
| Gene or Protein evidence | Furanodiene down-regulated the integrin αV expression, β-catenin expression, focal adhesion kinase (FAK) phosphorylation, Akt phosphorylation, and PI3 kinase p85 phosphorylation, and all of these were involved in modulation of the tumor metastasis process. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | An interference of metastasis was also observed in MDA-MB-231 cells through the regulation of the matrix metalloproteinase 9 (MMP-9) releases. Our results suggested that furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | At low concentrations (5-25μM), furanodiene inhibited adhesion, migration and invasion of breast cancer cells, but it did not induce cytotoxicity, apoptosis and cell cycle arrest. | |
| PubChem ID | 636458 | |
| Additional PMIDs | 22422660 28184941 24824922 22854281 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1009084-1 | |
| Safety | NA |