| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1658 | |
| Phytochemical name or plant extracts | Fucoxanthin | |
| PMID | 30648805 | |
| Literature evidence | The ability of fucoxanthin to inhibit lymphangiogenesis remains unclear. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Undaria pinnatifida | |
| Geographical availability | NA | |
| Plant parts | Brown algae | |
| Other cancers | Breast cancer | |
| Target gene or protein | TIMP‐1, MMP2, MMP9 | |
| Gene or Protein evidence | The results indicated that fucoxanthin decreased the expression and secretion of MMP‐2 and MMP‐9 but increased expression and secretion of TIMP‐1 | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Fucoxanthin also decreased micro-lymphatic vascular density (micro-LVD) in a MDA-MB-231 nude mouse model of breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | To evaluate the effect of fucoxanthin on VEGF‐C secretion, ELISA and Real‐time qPCR assays were used to measure VEGF‐C expression and secretion in MDA‐MB‐231 cells. The results showed that mRNA expression and secretion were down‐regulated in the presence of fucoxanthin | |
| PubChem ID | 5281239 | |
| Additional PMIDs | 25550553 | |
| Additional sources of information | NA | |
| Safety | NA |