| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1490 | |
| Phytochemical name or plant extracts | Fucoidan | |
| PMID | 19754176 | |
| Literature evidence | Author information: (1)Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. yumi_mi_1111@yahoo.co.jp Fucoidan is an active component of seaweed that has been shown to inhibit proliferation and induce apoptotic cell death in several tumor cells. | |
| IUPAC name | [(2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyloxan-3-yl] hydrogen sulfate | |
| Phytochemicals’ class or type of plant extracts | Sulfated polysaccharides | |
| Source of phytochemicals or plant Extracts | Brown algae | |
| Geographical availability | Sea | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TGFRI and TGFRII proteins, Smad2/3, Smad4 , TGF?, Bid, Caspase 7, Caspase 8, Caspase 9, PARP | |
| Gene or Protein evidence | Fucoidan decreases TGFRI and TGFRII proteins and affects downstream signaling molecules, including Smad2/3 phosphorylation and Smad4 expression. Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer. Furthermore, expression of Bid was decreased, whereas truncated Bid was increased by fucoidan treatment. Results from the apoptosis assay demonstrated that fucoidan induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspase-7, -8, and -9, and cleavage of poly(ADP ribose) polymerase. | |
| Target pathways | ROS-dependent JNK activation and mitochondria-mediated pathways | |
| IC50 | NA | |
| Potency | Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, T47D, 4T1 xenograft female Balb/c mice | |
| Additional information | Using 4T1 and MDA-MB-231 cells, we found that fucoidan effectively reverses TGFR-induced EMT morphological changes, upregulates epithelial markers, downregulates mesenchymal markers and decreases the expression of transcriptional repressors Snail, Slug and Twist. 2. Anticancer effect of fucoidan in combination with tyrosine kinase inhibitor lapatinib. | |
| PubChem ID | 129532628 | |
| Additional PMIDs | 29141543 23275155 23303302 29156992 22096572 19754176 22492498 23391903 24587811 | |
| Additional sources of information | NA | |
| Safety | NA |