| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-355 | |
| Phytochemical name or plant extracts | Friedelin | |
| PMID | 28619518 | |
| Literature evidence | In conclusion, friedelin effectively inhibit breast cancer MCF-7 cell growth, it was associated with early expression of Cdkn1a, pRb2 and activation of p53 and caspases. | |
| IUPAC name | (4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1H-picen-3-one | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Garcinia penangiana | |
| Geographical availability | Borneo, Malaya, Sumatera | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | CDKN1a, pRb2, p53, Nrf2, Caspase 3, Bcl-2, mdm2, PCNA | |
| Gene or Protein evidence | Apoptosis was confirmed by significantly (p≤0.001) increased tumor suppressor gene Cdkn1a, pRb2, p53, Nrf2, caspase-3 and decreased Bcl-2, mdm2 & PCNA expression after 48h. | |
| Target pathways | NA | |
| IC50 | 1.8μM for 24h against MCF-7 1.2μM for 48h against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In conclusion, friedelin effectively inhibit breast cancer MCF-7 cell growth, it was associated with early expression of Cdkn1a, pRb2 and activation of p53 and caspases. | |
| PubChem ID | 91472 | |
| Additional PMIDs | 8134418 31660940 17602714 28619518 18274278 16883274 20045980 23274776 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428167-1 | |
| Safety | NA |