| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1488 | |
| Phytochemical name or plant extracts | Fresh Yellow Onion | |
| PMID | 26625755 | |
| Literature evidence | Our findings for the first time showed that regular onion administration could be effective for hepatic enzyme conveying adjuvant chemotherapy relevant toxicity and reducing the tumor markers in BC during doxorubicin-based chemotherapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Allium cepa | |
| Geographical availability | Turkmenistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | CEA, CA125 | |
| Gene or Protein evidence | Effects of Fresh Yellow Onion Consumption on CEA, CA125 and Hepatic Enzymes in Breast Cancer Patients: A Double- Blind Randomized Controlled Clinical Trial | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our findings for the first time showed that regular onion administration could be effective for hepatic enzyme conveying adjuvant chemotherapy relevant toxicity and reducing the tumor markers in BC during doxorubicin-based chemotherapy. Study results suggest that high onion and garlic consumption is protective against breast cancer in this population. | |
| Cell line/ mice model | NA | |
| Additional information | Inverse associations with breast cancer were observed for moderate (OR (odds ratio) = 0.59, 95% CI (confidence interval): 0.35, 1.01) and high consumption (OR = 0.51, 95% CI: 0.30, 0.87) compared to low consumption of onion and garlic (Ptrend = 0.02). 2. The adjusted odds ratio for the consumption of more than one slice of onion per day and BC was 0.27 (95% confidence interval = 0.16-0.47), with a statistically significant trend (p < 0.001). | |
| PubChem ID | NA | |
| Additional PMIDs | 31402709 9928867 11142084 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:527795-1 | |
| Safety | NA |