| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-427 | |
| Phytochemical name or plant extracts | Fraction 35 (F035) | |
| PMID | 11454696 | |
| Literature evidence | Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Acacia victoriae | |
| Geographical availability | New South Wales, Northern Territory, Queensland, South Australia, Victoria, Western Australia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT | |
| Gene or Protein evidence | The triterpenoid saponins also partially inhibited phosphatidylinositol 3-kinase activity in Jurkat T cells in a time-dependent manner and phosphorylation in the downstream protein Akt, whereas no affect was seen on the Ras/mitogen-activated protein kinase cascade. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These observations as well as other work from our laboratory demonstrating mitochondrial perturbation, chemoprevention, and inhibition of nuclear factor kappaB suggest that triterpenoid saponins from A. victoriae have potential as novel anticancer agents. | |
| Cell line/ mice model | MDA-MB-453, MDA-MB-435 | |
| Additional information | F035 and the avicins induced cell cycle (G1) arrest of the human MDA-MB-453 breast cancer cell line and apoptosis of the Jurkat (T-cell leukemia) and the MDA-MB-435 breast cancer cell line. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:471757-1 | |
| Safety | NA |