| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2190 | |
| Phytochemical name or plant extracts | Forskolin | |
| PMID | 29574069 | |
| Literature evidence | Recently, forskolin is emerging as a possible novel molecule for cancer therapy. | |
| IUPAC name | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Labdane diterpenoid | |
| Source of phytochemicals or plant Extracts | Coleus barbatus | |
| Geographical availability | Burundi, China South-Central, East Himalaya, Eritrea, Ethiopia, India, Kenya, Nepal, Oman, Rwanda, Saudi Arabia, Somalia, Sri Lanka, Sudan, Tanzania, Thailand, Uganda, West Himalaya, Yemen, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | ERK1/2 | |
| Gene or Protein evidence | Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our findings sustain the evidence of anticancer activity mediated by forskolin and encourage the design of future in-vivo/clinical studies in order to explore forskolin as a doxorubicin sensitizer for possible use in TNBC patients. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MCF7, HeLa | |
| Additional information | It is important to note that the forskolin-induced potentiation of sensitivity to doxorubicin is accompanied by a strong inhibition of ERK1/2 phosphorylation, is mimicked by ERK inhibitor PD98059 and is prevented by pre-treatment with Protein Kinase A (PKA) and adenylate cyclase inhibitors. Altogether, our data indicate that forskolin sensitizes TNBC cells to doxorubicin via a mechanism depending on the cAMP/PKA-mediated ERK inhibition. | |
| PubChem ID | 47936 | |
| Additional PMIDs | 24593874 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60454692-2 | |
| Safety | NA |