| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-679 | |
| Phytochemical name or plant extracts | Formosanin C | |
| PMID | 35204181 | |
| Literature evidence | Our data suggest a therapeutic strategy by ferroptosis against TNBC, an aggressive subtype with a poor prognosis. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Trachycarpus fortunei | |
| Geographical availability | China South-Central, Myanmar | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Focal adhesion-PI3K-Akt-mTOR-signaling pathway | |
| IC50 | NA | |
| Potency | FC sensitized cisplatin-induced ferroptosis in MDA-MB-231 cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Our data suggest a therapeutic strategy by ferroptosis against TNBC, an aggressive subtype with a poor prognosis. FC exhibited the strongest cell growth inhibition among all tested phytochemicals and anti-cancer drugs, including cisplatin, in MDA-MB-231. | |
| PubChem ID | 21603986 | |
| Additional PMIDs | 35204181 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:670182-1 | |
| Safety | NA |