| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1306 | |
| Phytochemical name or plant extracts | Foeniculum vulgare extract | |
| PMID | 25588942 | |
| Literature evidence | The ethanol extract of Foeniculum vulgare was found to exhibit the most significant toxicity with an IC50 value of 19.97 μg/mL on HeLa cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Foeniculum vulgare | |
| Geographical availability | Afghanistan, Albania, Algeria, Baleares, Bulgaria, Corse, Cyprus, East Aegean Is., Egypt, Eritrea, Ethiopia, France, Greece, Gulf States, Iran, Iraq, Italy, Kriti, Lebanon-Syria, Libya, Morocco, Nepal, North Caucasus, Pakistan, Palestine, Portugal, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Uzbekistan, West Himalaya, Yemen, Yugoslavia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 50 µg/mL against MCF-7 | |
| Potency | Exhibits immunomodulatory NFkappaB activity Suppresses the growth of MCF-7 cells ( fennel(Foeniculum vulgare) nsLTP1 ) Increases the expression of Bax, but decreases Bcl2 gene expression significantly (P < 0.001). | |
| Cell line/ mice model | MCF-7, MDA-Mb, Hela | |
| Additional information | It was evident from the cytotoxicity results that F. vulgare showed high potential as an anticancer agent, specifically against the HeLa cell line. | |
| PubChem ID | NA | |
| Additional PMIDs | 17716845 28980930 33116517 33277525 31069662 29308661 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842680-1 | |
| Safety | NA |