| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1860 | |
| Phytochemical name or plant extracts | Flavokawain A | |
| PMID | 26179368 | |
| Literature evidence | Apart from that, flavokawain A also decreased the weight and volume of the tumor, and managed to induce apoptosis in them. | |
| IUPAC name | (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Piper methsyticum | |
| Geographical availability | Piper methysticum being a tropical species requires tropical conditions to fl ourish. It thrives best in loose, well-drained, moist, wellcomposted soils in a protected, partially shaded position, between 300 and 500 m above sea level in a tropical environment of 20–35 °C, 70–100 % relative humidity and rainfall above 2000 mm per annuum. | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | IFN-γ, IL-2, NO, iNOS, NF-κB, ICAM, COX-2 | |
| Gene or Protein evidence | The levels of IFN-γ and IL-2 were also elevated in the serum of flavokawain A-treated mice. In terms of inflammation, flavokawain A-treated mice had reduced level of major pro-inflammatory mediators, NO, iNOS, NF-KB, ICAM and COX-2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Based on our study, it is interesting to note that flavokawain A increased the T cell population, both Th1 cells and CTLs, aside from the natural killer cells. | |
| Cell line/ mice model | Breast cancer murine model | |
| Additional information | Overall, flavokawain A has the potential to not only enhance antitumor immunity, but also prevents the inflammatory process in a cancer-prone microenvironment. | |
| PubChem ID | 5355469 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |