| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-425 | |
| Phytochemical name or plant extracts | Fisetin | |
| PMID | 34267320 | |
| Literature evidence | We observed that breast tumor cells treated with fisetin show a 20-30% decreased nucleolar abundance per cell and a 30-60% downregulation of RNA Pol I transcription activity, as well as a 50-70% reduction in nascent rRNA synthesis, depending on the cell line. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Acacia carneorum Acacia buxifolia | |
| Geographical availability | Acacia carneorum - New South Wales, South Australia Acacia buxifolia - New South Wales, Queensland, Victoria | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | PTEN | |
| Gene or Protein evidence | Furthermore, fisetin suppressed phosphoinositol 3-kinase (PI3K)-Akt-GSK-3β signaling pathway but upregulated the expression of PTEN mRNA and protein in a concentration-dependent manner. | |
| Target pathways | PTEN/Akt/GSK-3β signaling pathway MAPK/ERK pathway | |
| IC50 | NA | |
| Potency | Therefore, fisetin may be useful as a potential therapeutic agent for the treatment of metastatic breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, BT-549 | |
| Additional information | Fisetin modulates the cytoskeletal structure of endothelial cells by increasing microtubule stability and thus displays antiangiogenic activity | |
| PubChem ID | 5281614 | |
| Additional PMIDs | 30108501 30076913 21922137 24294925 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:469945-1 , | |
| Safety | NA |