| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-918 | |
| Phytochemical name or plant extracts | Ficus septica extract | |
| PMID | 23620854 | |
| Literature evidence | CONCLUSIONS: Based on this results, HIF is potential to be developed as co-chemotherapeutic agent for breast cancer by inducing apoptosis and cell cycle arrest. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | n-hexane insoluble fraction (HIF) | |
| Source of phytochemicals or plant Extracts | Ficus septica | |
| Geographical availability | Bismarck Archipelago, Borneo, Jawa, Lesser Sunda Is., Malaya, Maluku, Nansei-shoto, New Guinea, Philippines, Queensland, Santa Cruz Is., Solomon Is., Sulawesi, Sumatera, Taiwan, Vanuatu | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP | |
| Gene or Protein evidence | It showed that combinational treatment upregulated c-PARP on T47D cells. | |
| Target pathways | NA | |
| IC50 | 9 µg/mL against T47D | |
| Potency | Based on this results, HIF is potential to be developed as co-chemotherapeutic agent for breast cancer by inducing apoptosis and cell cycle arrest. | |
| Cell line/ mice model | T47D | |
| Additional information | Based on the results, we concluded that combination of n-HIF of F. septica leaves and doxorubicin synergically increases the cytotoxic effect of doxorubicin through apoptosis (cell death induction), increase of cleaved-PARP expression and cell cycle arrest. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:853688-1 | |
| Safety | NA |