| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-917 | |
| Phytochemical name or plant extracts | Ficus salicifolia latex | |
| PMID | 34121859 | |
| Literature evidence | F. salicifolia grows in a harsh dry environment, therefore its latex was selected in the current study along with the F. carica for their comparative anti-cancer potential and the involved molecular mechanism. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Ficus salicifolia | |
| Geographical availability | Algeria, Botswana, Central African Repu, Chad, Djibouti, Egypt, Eritrea, Ethiopia, Gulf States, Kenya, KwaZulu-Natal, Libya, Malawi, Mozambique, Niger, Northern Provinces, Oman, Saudi Arabia, Socotra, Somalia, Sudan, Swaziland, Tanzania, Uganda, Yemen, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERK2, CREB, AKT2 | |
| Gene or Protein evidence | We found that ERK2, CREB, and AKT2 were downregulated after treatment the MDA-Mb-231 cells with the latex of F. carica. | |
| Target pathways | This also support the idea that F. carica might cause anoikis and reduce metastasis after it downregulated both ERK and Akt pathways | |
| IC50 | NA | |
| Potency | In conclusion, leaves latex of F. carica and F. salicifolia share anticancer potential in MDA-MB-231 cells showing antiproliferative and anti-metastatic effects along with significant effects on cell shape. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | F. salicifolia is a native plant in United Arab Emirates (UAE) which is used traditionally against scorpion stings, bruises, skin and chest inflammation and cough etc. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:853634-1 | |
| Safety | NA |