| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-916 | |
| Phytochemical name or plant extracts | Ficus hispida extract | |
| PMID | 29197545 | |
| Literature evidence | The aim of this study was to evaluate the cancer chemopreventive and anticancer activities of crude extracts of F. hispida, with the objective to screen the inhibition of Epstein-Barr virus early antigen, and cytotoxic active components, and provide foundation for potential applications of this promising medical plant. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Ficus hispidaf | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Nicobar Is., Northern Territory, Queensland, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer, Cervical cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Five compounds, isowigtheone hydrate (1), 2, 3, 9, and 19, showed potent inhibitory effects on EBV-EA induction with IC50 values in the range of 271-340 molar ratio 32 pmol-1 TPA. In addition, five phenolic compounds, 1-3, 10, and 13, exhibited cytotoxic activity against two or more cell lines (IC50 2.5-95.8μM) | |
| Potency | This study has established that the MeOH extract of F. hispida fruits contains isoflavones, coumarins, caffeoylquinic acids, along with other compounds including phenolics and steroid glucoside as active principles, and has demonstrated that the chemical constituents of F. hispida may be valuable as potential chemopreventive and anticancer agents. | |
| Cell line/ mice model | SKBR-3, HL60, A549, KB, Hela, HT29, HepG2 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 29197545 25468714 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:852981-1 | |
| Safety | NA |