| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-915 | |
| Phytochemical name or plant extracts | Ficus crocata extracts | |
| PMID | 32571387 | |
| Literature evidence | BACKGROUND: Some species of the Ficus genus show pharmacological activity, including antiproliferative activity, in cell lines of several cancer Types. ficus crocata is distributed in Mexico and used in traditional medicine, as it is believed to possess anti-inflammatory, analgesic, and antioxidant properties. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane (Hex-EFc), Dichloromethane (Dic-EFc) extract, Acetone (Ace-EFc) extract | |
| Source of phytochemicals or plant Extracts | Ficus crocata | |
| Geographical availability | Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Haiti, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Procaspase 8, Procaspase 3 | |
| Gene or Protein evidence | Dic-EFc was fractioned and its antiproliferative activity was potentiated, which enhanced its ability to induce apoptosis in MDA-MB-231 cells, as well as increased p53, procaspase-8, and procaspase-3 expression. | |
| Target pathways | NA | |
| IC50 | For 48h: Dic-EFc - 32.43 μg/mL against MDA-MB-231 Ace-EFc - 78.49 μg/mL against MDA-MB-231 Hex-EFc - 164.05 μg/mL against MDA-MB-231 | |
| Potency | This study provides information on the biological activity of F. crocata extracts and suggests their potential use against triple-negative breast cancer. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | It was observed that the Dic-EFc treatment induced apoptosis in 4.3 and 7.7% of the cell population with 20 μg mL− 1 and 40 μg mL− 1, respectively, while 80 μg mL− 1 increased the apoptotic population to 19.3% (4.3 and 15% in early and late apoptosis, respectively). Interestingly, the fractionation of Dic-EFc components enhanced the ability of the extract to induce apoptosis in MDA-MB-231 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:852689-1 | |
| Safety | NA |