| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-898 | |
| Phytochemical name or plant extracts | Ferulin C | |
| PMID | 31863866 | |
| Literature evidence | Based upon the RNAseq analysis, PAK1, as a novel essential modulator, was involved in the signaling regulated by Ferulin C -induced α/β-tubulin depolymerization. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene coumarin | |
| Source of phytochemicals or plant Extracts | Ferula ferulaeoides | |
| Geographical availability | Kazakhstan, Mongolia, Xinjiang | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | Based upon the RNAseq analysis, PAK1, as a novel essential modulator, was involved in the signaling regulated by Ferulin C -induced α/β-tubulin depolymerization. | |
| Target pathways | Ras-Raf-ERK and AKT-mTOR signaling | |
| IC50 | Ferulin C presented potent antiproliferatory activity against MCF-7 and MDA-MB-231 cells and remarkable tubulin polymerization inhibitory activity (IC50 = 9.2 μM). | |
| Potency | Summarily, our findings substantiated that Ferulin C was a potent, colchicine site binding microtubule-destabilizing agent with anti-proliferation and anti-metastasis activity via PAK1 and p21-mediated signaling in breast cancer cells. | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | Additionally, Ferulin C displayed an acceptable antiproliferatory activity in an MCF-7 xenograft model without inducing obvious weight loss in the Ferulin C treated mice. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842271-1 | |
| Safety | NA |