| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1061 | |
| Phytochemical name or plant extracts | Ferulic acid | |
| PMID | 28939230 | |
| Literature evidence | The optimal concentration of DPPH was determined, and six potential antioxidants including 4-hydroxyphenylacetic acid, p-coumaric acid, ferulic acid, quercitrin, astragalin, and quercetin, and three non-antioxidants including benzoic acid, coptisine, and berberine, were successfully screened out and validated by conventional DPPH radical scavenging activity assay. | |
| IUPAC name | (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Phenolic acid | |
| Source of phytochemicals or plant Extracts | Angelica sinensis | |
| Geographical availability | China North-Central, China South-Central, Inner Mongolia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Pancreatic cancer | |
| Target gene or protein | HER2, ESR1 | |
| Gene or Protein evidence | The HER2 oncogene (one of the prognostic factors of breast cancer) and ESR1 gene (oestrogen receptor-alpha, ERα) transcription were markedly up-regulated by FA treatment. Besides, HER2 signalling and its downstream molecules such as AKT and ERK1/2 were involved in FA-modulated ERalpha and cyclin D1 synthesis. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Based on the results of cellular carried out in this study, we could demonstrate that asafoetida and its essential oil and ferulic acid have inhibitory effect on the growth of breast cancer cell line. | |
| Cell line/ mice model | MCF-7, BT-474, MDA- MB-231, SKBR-3 | |
| Additional information | NA | |
| PubChem ID | 445858 | |
| Additional PMIDs | 28900317 24488720 25098952 15971118 12358499 25677620 29164418 16893382 17075435 28324297 14979919 16848520 20560113 27573001 27618000 31493741 34083561 34227213 34064100 33968897 32847047 31526250 31204854 30663386 23123452 26147490 27588384 28351770 29642867 30678123 16562825 18813848 18592868 23448448 30176347 34320049 11097223 18476702 33491801 23703112 22481537 25762472 27123037 28850929 10630125 32429317 30949219 34234213 21464939 25285637 26958638 31440879 24827745 28939230 34857023 31263506 11714372 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77065778-1 | |
| Safety | NA |