| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1273 | |
| Phytochemical name or plant extracts | Ferulago angulata extract | |
| PMID | 25996383 | |
| Literature evidence | The aims of the present study were to investigate the in vivo chemopreventive effect of FALHE in rats, to identify the contributing anticancer compound in FALHE and to determine its potential mechanism of action against MCF7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane extract | |
| Source of phytochemicals or plant Extracts | Ferulago angulata | |
| Geographical availability | Iraq, Pakistan, Turkey | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | PCNA, Ki67, Bax, p53, Caspase 3 | |
| Gene or Protein evidence | An in vivo study showed that FALHE suppressed the expression of the tumor markers PCNA and Ki67. FALHE administration induced apoptosis in breast tumor cells, and this was confirmed by high expression levels of Bax, p53 and caspase 3 | |
| Target pathways | FALHE suppressed the proliferation of MCF-7 cells via cell cycle arrest and the induction of apoptosis through intrinsic pathway. | |
| IC50 | 3.16 ± 0.31 µg/ml against MCF7 cells. | |
| Potency | Ferulago angulata leaf hexane extract (FALHE) was found to be a potent inducer of MCF7 cell apoptosis. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | FALHE administration induced apoptosis in breast tumor cells, and this was confirmed by high expression levels of Bax, p53 and caspase 3. Cell cycle arrest was suggested by the expression of p21 and p27. | |
| PubChem ID | NA | |
| Additional PMIDs | 25278746 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:842559-1 | |
| Safety | NA |