| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1554 |
| Phytochemical name or plant extracts | Farnesylthiosalicylic acid (FTS) |
| PMID | 15459249 |
| Literature evidence | Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. |
| IUPAC name | 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | s6k1, mTOR |
| Gene or Protein evidence | Recent results indicate that an inhibitor of the Ras signaling pathway, farnesylthiosalicylic acid (FTS), decreased phosphorylation of the mTOR effectors, PHAS-I and S6K1, in breast cancer cells. |
| Target pathways | Recent results indicate that an inhibitor of the Ras signaling pathway |
| IC50 | NA |
| Potency | NA |
| Cell line/ mice model | MCF-7 |
| Additional information | Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex. |
| PubChem ID | 5469318 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |