| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1084 | |
| Phytochemical name or plant extracts | Falcarindiol | |
| PMID | 24269959 | |
| Literature evidence | They display interesting bioactivities and hold potential as health-promoting and therapeutic agents. | |
| IUPAC name | (3R,8S,9Z)-heptadeca-1,9-dien-4,6-diyne-3,8-diol | |
| Phytochemicals’ class or type of plant extracts | Polyacetylene | |
| Source of phytochemicals or plant Extracts | Cnidium officinale | |
| Geographical availability | Japan | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | Bax , p53, Bcl-2 | |
| Gene or Protein evidence | In addition, falcarindiol induced apoptosis through strongly increased mRNA expression of Bax and p53, and slightly reduced Bcl-2 mRNA levels in a dose dependent manner. | |
| Target pathways | NA | |
| IC50 | 35.67 μM against MCF-7 | |
| Potency | Among these compounds, falcarindiol (1) was found to have anti-proliferative effect against MCF-7 human breast cancer cells by induction of a G(0)/G(1) cell cycle block of the cells, with an IC(50) value of 35.67 μM. | |
| Cell line/ mice model | MCF-7, HCT-116 | |
| Additional information | NA | |
| PubChem ID | 5281148 | |
| Additional PMIDs | 20723598 24269959 23746754 29766799 22019572 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:840466-1 | |
| Safety | NA |