| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1359 | |
| Phytochemical name or plant extracts | Extracts of Paeonia suffruticosa | |
| PMID | 28870900 | |
| Literature evidence | CONCLUSION: P. suffruticosa extract has the ability to modulate the production of several tumor suppressive cytokines, induce intrinsic apoptosis and has the capability of reducing cancer burden while sparing healthy tissue. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Paeonia suffruticosa | |
| Geographical availability | China Southeast | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | IL-6, IL-2, IL-24, Fas, Bcl-2, TNF-α | |
| Gene or Protein evidence | ELISA for IL-6, IL-2, and TNF-alpha revealed a biphasic dose-response inversely related to viability (p<0.05). IL-24 expression also increased at 2.5 mg/ml and 4.0 mg/ml (p<0.05). Bax levels remained relatively constant while Bcl-2 decreased significantly in all concentrations (p<0.01). Small decreases in Fas ligand levels was observed in parallel with a lack of increase in caspase-8 activity. | |
| Target pathways | It was concluded that P. suffruticosa does not induce apoptosis through an extrinsic pathway in MDA-MB-231, but through an intrinsic pathway, activating caspase 9 | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:711877-1 | |
| Safety | P. suffruticosa extract has the ability to modulate the production of several tumor suppressive cytokines, induce intrinsic apoptosis and has the capability of reducing cancer burden while sparing healthy tissue. |