| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1350 | |
| Phytochemical name or plant extracts | Extract of garden cress | |
| PMID | 23961228 | |
| Literature evidence | The ability of the extract to induce apoptosis and necrosis in the human breast cancer cell line MCF-7, compared to normal human skin fibroblasts (HFS), was determined by morphological changes in the cells using light microscopy, DNA fragmentation assay, and florescent stains (Annexin V and propidium iodide) using flow cytometry and fluorescent microscopy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Lepidium sativum | |
| Geographical availability | Bulgaria, Cyprus, East Aegean Is., Greece, Kriti, Lebanon-Syria, Palestine, Turkey, Turkey-in-Europe | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 6, Caspase 7 | |
| Gene or Protein evidence | May activate different apoptotic pathways and other effector caspases such as caspase-6 or -7 | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Finally, the results may indicate that apoptotic changes in MCF-7 may be independent of caspase-3, which is involved in apoptosis and is lacking in MCF-7 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:286421-1 | |
| Safety | NA |