| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-738 | |
| Phytochemical name or plant extracts | Extract of Spondias pinnata | |
| PMID | 23686547 | |
| Literature evidence | Flow cytometric analysis and confocal microscopic studies confirmed that SPME is able to induce apoptosis in both malignant cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Spondias pinnata | |
| Geographical availability | Andaman Is., Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, Pakistan, Philippines, Sri Lanka, Sulawesi, Thailand, Vietnam | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | Caspase 3, Caspase 9, PARP, Bax | |
| Gene or Protein evidence | The 17 kDa subunit of cleaved caspase-3 was clearly detected after 8 h of treatment in A549 and MCF-7 cells followed by a gradual increase in its level. The 17 kDa subunit of cleaved caspase-9 was found increasing with time in both types of cells. the expression of Bax was also found increasing in MCF-7 cell with no change in expression of Bcl-2. | |
| Target pathways | Death-receptor-induced extrinsic pathway , mitochondria-apoptosome-mediated intrinsic pathway | |
| IC50 | 149.34 ± 13.30 μg/ml against MCF-7 | |
| Potency | SPME inhibited the growth of both A549 and MCF-7 cells in a dose-dependent manner with an IC50 value of 147.84 ± 3.74 and 149.34 ± 13.30 μg/ml, respectively. | |
| Cell line/ mice model | MCF-7, A549 | |
| Additional information | SPME increased the number of cells in sub-G1 phase both in the case of A549 and MCF-7 dose dependently, which refers to the cells that underwent apoptosis. This sub-G1 population was quantified as the percentage of apoptosis. These results indicate SPME induced cell death in A549 and MCF-7 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:71489-1 | |
| Safety | The cytotoxicity of SPME on the normal fibroblast cell line was also evaluated, the results showed that treatment of WI-38 with the extract did not inhibit the cell proliferation significantly and the IC50 was calculated as 932.38 ± 84.44 μg/ml |