| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1375 | |
| Phytochemical name or plant extracts | Eurycoma longifolia Jack extract | |
| PMID | 16317660 | |
| Literature evidence | The results showed that all the root extracts except the water extract of E. longifolia produced significant cytotoxic effect on these cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanol, n-butanol, Chloroform and Aqueous extract | |
| Source of phytochemicals or plant Extracts | Eurycoma longifolia Jack | |
| Geographical availability | Borneo, Cambodia, Laos, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Squamous cell cancer, Prostate cancer, Myosarcoma, Ovarian cancer | |
| Target gene or protein | cyt-c, Caspase 3, Bax, Bcl-2, Bax, p53, Caspase -8, Caspase -7 | |
| Gene or Protein evidence | There were significant activities of cytochrome c, caspase-3, Bax, and Bcl-2 apoptotic protein in MDA-MB-231 cells, whereas MCF-7 cells showed significant activities for caspase-8, cytochrome c, Bax, p53, and Bcl-2 apoptotic protein. Intrinsic apoptotic pathway was invoked, with the reduction of Bcl-2 protein. Then, executioner caspase-7 was cleaved and activated in response to F16 treatment. | |
| Target pathways | Intrinsic apoptotic pathway | |
| IC50 | Methanol extract - 8.6 µg/mL against MCF-7 n-Butanol extract- 33.4 µg/mL against MCF-7 Chloroform extract - 21.7µg/mL against MCF-7 Aqueous extract - >100.0 µg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MCF-10A, KB, DU-145, RD, CaOV-3, MDA-MB-231 | |
| Additional information | Cell cycle was arrested at the G 2/M phase in MCF-7 cells and S phase in MDA-MB-231 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 17970090 33603822 16317660 24513570 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813715-1 | |
| Safety | NA |