| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-300 | |
| Phytochemical name or plant extracts | Euphorbia tirucalli Extracts | |
| PMID | 27028817 | |
| Literature evidence | These results suggest that the extracts might induce cell cycle arrest at G0/G1 with p21 attributing to this molecular mechanism. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Butanol extract, hexane extract, Methanolic extract | |
| Source of phytochemicals or plant Extracts | Euphorbia tirucalli | |
| Geographical availability | Angola, Botswana, Burundi, Cape Provinces, Caprivi Strip, Comoros, Ethiopia, India, Kenya, KwaZulu-Natal, Laccadive Is., Madagascar, Malawi, Maldives, Mozambique, Namibia, Nigeria, Northern Provinces, Pakistan, Rwanda, Somalia, Sri Lanka, Sudan, Swaziland, Tanzania, Uganda, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21, Bax, Caspase 8 | |
| Gene or Protein evidence | Analysis of the cause of antiproliferation revealed that most cells were arrested at the G0/G1 phase by p21 overexpression. In general, most pro-apoptotic genes like Bax and caspase-8 were significantly up-regulated in cells treated with plant extracts. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results suggest that the extracts might induce cell cycle arrest at G0/G1 with p21 attributing to this molecular mechanism. | |
| Cell line/ mice model | MCF-7, MDA-MB 231 | |
| Additional information | Extracts were found to contain different types of secondary metabolites mainly terpenes and flavonoids. Breast cancer cell lines (MCF-7 and MDA-MB 231) were treated with various concentrations of the extracts for up to 48 h. Cell viability, cell cycle, apoptosis and gene expression were analysed. In cells, extracts were found to inhibit cell proliferation in a concentration and cell type dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | 28487845 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:348517-1 | |
| Safety | NA |