| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-296 | |
| Phytochemical name or plant extracts | Euphorbia microsciadia extract | |
| PMID | 32603285 | |
| Literature evidence | Accordingly, targeting miRNAs by E. microsciadia can open some newer avenues for breast cancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hydroalcoholic extract | |
| Source of phytochemicals or plant Extracts | Euphorbia microsciadia | |
| Geographical availability | Afghanistan, Iran, Pakistan, Palestine | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Let-7, miR-15, miR-16, miR-29, miR-34a | |
| Gene or Protein evidence | Furthermore, it was confirmed that, E. microsciadia had augmented the expression levels of Let-7, miR-15, miR-16, miR-29, and miR-34a, which lead to an increase in apoptosis. | |
| Target pathways | NA | |
| IC50 | The half maximal Inhibitory Concentrations (IC50) were also equal to 275 and 240μg/ml for E. μsciadia, by passing 24 and 48h from the treatment, respectively. | |
| Potency | E. microsciadia could modulate some miRNAs involved in cell cycle arrest and apoptosis in MDA-MB-231 cell line. Accordingly, targeting miRNAs by E. microsciadia can open some newer avenues for breast cancer therapy. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:347354-1 | |
| Safety | NA |