| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1020 | |
| Phytochemical name or plant extracts | Euphorbia hirta extract | |
| PMID | 23998008 | |
| Literature evidence | OBJECTIVE: To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model using comet assay. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Euphorbia hirta | |
| Geographical availability | Alabama, Argentina Northeast, Argentina Northwest, Arizona, Aruba, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, California, Central American Pac, Chile Central, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, French Guiana, Georgia, Guatemala, Haiti, Honduras, Jamaica, Leeward Is., Louisiana, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Mississippi, Netherlands Antilles, Nevada, New Mexico, Nicaragua, North Carolina, Panamá, Paraguay, Peru, Puerto Rico, South Carolina, Southwest Caribbean, Texas, Trinidad-Tobago, Turks-Caicos Is., Utah, Venezuela, Venezuelan Antilles, Windward Is. | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 2, Caspase 6, Caspase 8, Caspase 9 | |
| Gene or Protein evidence | The caspase activity study revealed that E. hirta extract induced apoptosis through the caspase-3-independent pathway by the activation of caspase-2, 6, 8, and 9. | |
| Target pathways | NA | |
| IC50 | Euphorbia hirta hexane fraction, namely HFsub4 fraction, demonstrated highest activity among all the fractions tested with an IC50 value of 10.01 µg/mL at 24 h. | |
| Potency | The present study evaluated the potential cytotoxicity and genotoxicity of E. hirta which can apply in pharmaceutical products developments. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | E. hirta induced apoptotic cell death and suggests that E. hirta could be used as an apoptosis-inducing anticancer agent for breast cancer treatment with further detailed studies. | |
| PubChem ID | NA | |
| Additional PMIDs | 26154521 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:101651-2 | |
| Safety | The extract of E. hirta showed significant toxicity against brine shrimp with an LC₅₀ value of 620.382 µg/mL (24 h). |