| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1743 | |
| Phytochemical name or plant extracts | Euphorbia factor L1 | |
| PMID | 21308736 | |
| Literature evidence | Furthermore, EFL1 could enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. | |
| IUPAC name | [(1'R,2S,3'E,5'R,7'S,11'R,12'R,13'S,14'S)-1',11'-diacetyloxy-3',6',6',14'-tetramethyl-2'-oxospiro[oxirane-2,10'-tricyclo[10.3.0.05,7]pentadec-3-ene]-13'-yl] 2-phenylacetate | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Euphorbia lathyris | |
| Geographical availability | Kirgizstan, Pakistan, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ABCB1 | |
| Gene or Protein evidence | At the same time, EFL1 inhibited the efflux of ABCB1 in KBv200 and MCF-7/adr cells. | |
| Target pathways | NA | |
| IC50 | 65.31+- 4.29 µM against MCF-7 | |
| Potency | These results indicated that EFL1 was apotent reversal agent to ABCB1-mediated MDR. | |
| Cell line/ mice model | C6, MCF-7, KBv200 | |
| Additional information | NA | |
| PubChem ID | 11238221 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:347072-1 | |
| Safety | NA |