| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-145 | |
| Phytochemical name or plant extracts | Eupalinolide O | |
| PMID | 27666560 | |
| Literature evidence | Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. | |
| IUPAC name | [(3aR,4R,6E,9S,10E,11aR)-9-acetyloxy-6-formyl-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Eupatorium lindleyanum | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Hainan, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Myanmar, Nansei-shoto, Philippines, Primorye, Qinghai, Taiwan, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin B1, cdc2 | |
| Gene or Protein evidence | The expression of cell cycle-related proteins (cyclin B1 and cdc2) was significantly decreased. | |
| Target pathways | Akt pathway | |
| IC50 | NA | |
| Potency | Collectively, EO suppressed the growth of the MDA-MB‑468 cells possibly by cell cycle arrest in the G2/M phase and the induction of caspase-dependent apoptosis. These results suggest that EO is a promising natural compound for breast cancer therapy. | |
| Cell line/ mice model | MDA-MB-468 | |
| Additional information | Further study demonstrated that EO induced apoptotic cell death in the MDA-MB-468 cells through the activation of caspases. The effect of EO on the induction of apoptosis was significantly prevented by the treatment of pan-caspase inhibitor Z-VAD-FMK. We also found that EO treatment resulted in cell cycle arrest in the G2/M phase. | |
| PubChem ID | 154809464 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:206259-1 | |
| Safety | NA |