| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1001 | |
| Phytochemical name or plant extracts | Eupafolin | |
| PMID | 33692864 | |
| Literature evidence | Therefore, the findings provide novel insights regarding the use of Eupafolin for the treatment of breast cancer. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Eupatorium album | |
| Geographical availability | Alabama, Connecticut, Delaware, Florida, Georgia, Louisiana, Maryland, Mississippi, New Jersey, New York, North Carolina, Ohio, Pennsylvania, South Carolina, Tennessee, Virginia, West Virginia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Caspase 3, Bcl-2, PI3K, AKT, mTOR | |
| Gene or Protein evidence | The protein levels of Bax and cleaved caspase 3 increased, whereas that of Bcl-2 decreased. Furthermore, results from western blotting indicated that Eupafolin treatment decreased the protein levels of p-PI3K, p-Akt and p-mTOR. | |
| Target pathways | PI3K/Akt/mTOR pathway | |
| IC50 | NA | |
| Potency | Taken together, the present findings demonstrate that Eupafolin has a significant inhibitory effect on the proliferation of EO771 cells, inhibits cell migration and invasion, and promotes cell apoptosis, thereby causing G0/G1 phase arrest, at least partially through the PI3K/Akt/mTOR signaling pathway. | |
| Cell line/ mice model | EO771 | |
| Additional information | The data showed that the proliferation, migration and invasion ability of EO771 cells treated with Eupafolin was significantly decreased, and the apoptosis rate was increased compared with that of the control. | |
| PubChem ID | 5317284 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:99450-2 | |
| Safety | NA |