| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1190 | |
| Phytochemical name or plant extracts | Eugenol | |
| PMID | 17998642 | |
| Literature evidence | Investigations in our laboratory have focused on the mechanism of activity of variety of anticancer and antioxidant agents, namely, Eugenol, (EU), Ellagic acid (EA), Triphala (TPL), Tocopherol Succinate (TOS) and Arachidonic acid on normal and cancer cells with view to design effective protocols in practical radioprotection and cancer radiotherapy. | |
| IUPAC name | 2-methoxy-4-prop-2-enylphenol | |
| Phytochemicals’ class or type of plant extracts | Phenol | |
| Source of phytochemicals or plant Extracts | Syzygium aromaticum | |
| Geographical availability | Maluku | |
| Plant parts | Buds and Leaves | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | LC3, NUp62, E2F1/survivin | |
| Gene or Protein evidence | Eugenol also induced autophagy by upregulating the expression levels of microtubule-associated protein 1 light chain 3 (LC3) and downregulating the expression of nucleoporin 62 (NU p62). The inhibition of cancer cell proliferation is mainly due to the presence of eugenol, a phenolic natural compound which targets E2F1/survivin in cancer cells | |
| Target pathways | Eugenol alleviated breast precancerous lesions through HER2/PI3K-AKT pathway-induced cell apoptosis and S-phase arrest. | |
| IC50 | 8µM against MCF-7 | |
| Potency | Eugenol is a promising natural anti-cancer agent against triple-negative and HER2-positive breast cancer. Eugenol (which is also present in MO bark) in MDA-MB-231 cell apoptosis by increasing Bax protein expression. | |
| Cell line/ mice model | MCF-7, HeLa, MDA-MB-231 | |
| Additional information | Eugenol restricts Cancer Stem Cell population by degradation of beta-catenin via N-terminal Ser37 phosphorylation-an in vivo and in vitro experimental evaluation. | |
| PubChem ID | 3314 | |
| Additional PMIDs | 24689305 30661057 33224243 26288313 27245453 28915591 34502165 33867344 35174765 28272477 33509300 20034800 33988201 32321015 23144548 31926151 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:601421-1 | |
| Safety | NA |