| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-92 | |
| Phytochemical name or plant extracts | Esculetin | |
| PMID | 24647035 | |
| Literature evidence | These active compounds might be promising lead compounds for the treatment of cancer. | |
| IUPAC name | 6,7-dihydroxychromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Dryopteris fragrans | |
| Geographical availability | Alaska, Alberta, Altay, Amur, British Columbia, Buryatiya, China North-Central, Chita, Finland, Greenland, Inner Mongolia, Irkutsk, Japan, Kamchatka, Khabarovsk, Korea, Krasnoyarsk, Labrador, Magadan, Maine, Manchuria, Manitoba, Michigan, Minnesota, Mongolia, New Brunswick, New Hampshire, New York, Newfoundland, North European Russi, Northwest Territorie, Nova Scotia, Ontario, Primorye, Québec, Sakhalin, Saskatchewan, Tuva, Vermont, West Siberia, Wisconsin, Xinjiang, Yakutskiya, Yukon | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 2.73 ± 0.86 μM against MCF-7 | |
| Potency | Linoleic acid also increased MDA-MB-435 cell invasion in an in vitro assay, this stimulation was abolished by 20 microM esculetin, but was unaffected by piroxicam, a selective cyclooxygenase inhibitor. | |
| Cell line/ mice model | A549, MCF-7 , MDA-MB-435, MDA-MB-231, HepG2 | |
| Additional information | Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Compound 2 is esculetin | |
| PubChem ID | 5281416 | |
| Additional PMIDs | 21741969 24647035 15579072 2224849 8605728 33855849 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:17095220-1 | |
| Safety | NA |